Skip Navigation



Acta Biochimica et Biophysica Sinica Advance Access published online on May 8, 2009
Acta Biochimica et Biophysica Sinica, doi:10.1093/abbs/gmp035
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
41/6/472    most recent
gmp035v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Huang, B.
Right arrow Articles by Jin, Y.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Huang, B.
Right arrow Articles by Jin, Y.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2009. Published by ABBS Editorial Office in association with Oxford University Press on behalf of the Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences.

MicroRNA expression profiling in diabetic GK rat model

Bing Huang1,{dagger}, Wenming Qin1,{dagger}, Botao Zhao1, Yi Shi1, Chengguo Yao1, Jin Li2, Huasheng Xiao3 and Youxin Jin1,*

1 State Key Laboratory of Molecular Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
2 St Luke's Hospital, Shanghai 200050, China
3 National Engineering Center for Biochip at Shanghai, Zhangjiang High-Tech Park, Pudong, Shanghai 201203, China

* Correspondence address. Tel: +86-21-54921222; Fax: +86-21-54921011; E-mail: yxjin{at}sibs.ac.cn


  Abstract

MicroRNAs (miRNAs), which are a newly identified class of small single-stranded non-coding RNAs, regulate their target genes via post-transcriptional pathway. It has been proved that miRNAs play important roles in many biological processes. To better understand miRNA function on type 2 diabetes, we used an oligonucleotide microarray to monitor miRNA expression profiles of Goto–Kakizaki (GK) and Wistar rats' skeletal muscle. It was found that seven miRNAs were down-expressed and two miRNAs were over-expressed in the muscle of GK rats. Among them, miR-24 showed the most prominent change. p38 MAPK, which is a direct target of miR-24, also showed expression difference. All the data give a clue that miR-24 might be associated with diabetes through down-regulation of p38 MAPK.

Keywords    microRNA; diabetes; GK (Goto–Kakizaki) rat; Wistar rat; p38 MAPK

Received: December 16, 2008; Accepted: April 9, 2009

# These authors contributed equally to this work.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.