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Acta Biochimica et Biophysica Sinica Advance Access published online on April 29, 2009
Acta Biochimica et Biophysica Sinica, doi:10.1093/abbs/gmp032
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© The Author 2009. Published by ABBS Editorial Office in association with Oxford University Press on behalf of the Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences.

Sequences near both termini of the C/EBPβ mRNA 3'-untranslated region are important for its tumor suppression activity

Hai-Zhen Wang, Ying Wang, Li Sun and Ding-Gan Liu*

State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China

* Correspondence address. Tel: +86-21-54921135; Fax: +86-21-54921011; E-mail: dgliu{at}sibs.ac.cn, kinverskur{at}sohu.com


  Abstract

The 3'-untranslated region (3'UTR) of eukaryotic mRNA is an important regulation element that not only affects the mRNA's translation, but also cell growth. We had found that the 3'UTR of CCAAT-enhancer-binding protein β (C/EBPβ) mRNA has tumor suppression activity. Herein, we report that deletion of two short sequences at both termini of the C/EBPβ 3'UTR reduces the tumor suppression activity of this 3'UTR, as demonstrated by reduced cell growth, colony formation ability, and tumorigenicity in nude mice. It is noteworthy that deletion of a single such sequence only was enough for the reduction of tumor suppression effect, and the reducing effect of deletion of the sequence near 3'-terminus was stronger. Therefore, specific short sequences in the C/EBPβ 3'UTR are crucial for the tumor suppression activity of C/EBPβ.

Keywords    C/EBPβ 3'UTR; tumor suppression; deletion

Received: January 7, 2009; Accepted: April 7, 2009
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