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Acta Biochimica et Biophysica Sinica Advance Access published online on March 31, 2009
Acta Biochimica et Biophysica Sinica, doi:10.1093/abbs/gmp015
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© The Author 2009. Published by ABBS Editorial Office in association with Oxford University Press on behalf of the Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences.

Homologue of mammalian apolipoprotein A-II in non-mammalian vertebrates

Malay Choudhury1, Shoji Yamada2, Masaharu Komatsu2, Hideki Kishimura3 and Seiichi Ando1,2,*

1 Science of Marine Resources, United Graduate School of Agricultural Science, Kagoshima University, Korimoto, Kagoshima 890-0065, Japan
2 Department of Fisheries Science, Kagoshima University, Shimoarata, Kagoshima 890-0056, Japan
3 Department of Marine Bioresources Chemistry, Graduate School of Fisheries Sciences, Hokkaido University, Hakodate, Hokkaido 041-8611, Japan

* Correspondence address. Tel: +81-99-286-4201; Fax: +81-99-286-4015; E-mail: ando{at}fish.kagoshima-u.ac.jp


  Abstract

Although apolipoprotein with molecular weight 14 kDa (apo-14 kDa) is associated with fish plasma high-density lipoproteins (HDLs), it remains to be determined whether apo-14 kDa is the homologue of mammalian apoA-II. We have obtained the full cDNA sequences that encode Japanese eel and rainbow trout apo-14 kDa. Homologues of Japanese eel apo-14 kDa sequence could be found in 14 fish species deposited in the DDBJ/EMBL/GenBank or TGI database. Fish apo-14 kDa lacks propeptide and contains more internal repeats than mammalian apoA-II. Nevertheless, phylogenetic analysis allowed fish apo-14 kDa to be the homologue of mammalian apoA-II. In addition, in silico cloning of the TGI, Ensembl, or NCBI database revealed apoA-IIs in dog, chicken, green anole lizard, and African clawed frog whose sequences had not so far been available, suggesting both apoA-I and apoA-II as fundamental constituents of vertebrate HDLs.

Keywords    apolipoprotein A-II-like protein; Anguilla japonica; Oncorhynchus mykiss; phylogenetic tree; propeptide

Received: November 7, 2008; Accepted: March 3, 2009
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