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Acta Biochimica et Biophysica Sinica Advance Access originally published online on May 8, 2009
Acta Biochimica et Biophysica Sinica 2009 41(6):472-477; doi:10.1093/abbs/gmp035
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© The Author 2009. Published by ABBS Editorial Office in association with Oxford University Press on behalf of the Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences.

MicroRNA expression profiling in diabetic GK rat model

Bing Huang1,{dagger}, Wenming Qin1,{dagger}, Botao Zhao1, Yi Shi1, Chengguo Yao1, Jin Li2, Huasheng Xiao3 and Youxin Jin1,*

1 State Key Laboratory of Molecular Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
2 St Luke's Hospital, Shanghai 200050, China
3 National Engineering Center for Biochip at Shanghai, Zhangjiang High-Tech Park, Pudong, Shanghai 201203, China

* Correspondence address. Tel: +86-21-54921222; Fax: +86-21-54921011; E-mail: yxjin{at}sibs.ac.cn


  Abstract

MicroRNAs (miRNAs), which are a newly identified class of small single-stranded non-coding RNAs, regulate their target genes via post-transcriptional pathway. It has been proved that miRNAs play important roles in many biological processes. To better understand miRNA function on type 2 diabetes, we used an oligonucleotide microarray to monitor miRNA expression profiles of Goto–Kakizaki (GK) and Wistar rats' skeletal muscle. It was found that seven miRNAs were down-expressed and two miRNAs were over-expressed in the muscle of GK rats. Among them, miR-24 showed the most prominent change. p38 MAPK, which is a direct target of miR-24, also showed expression difference. All the data give a clue that miR-24 might be associated with diabetes through down-regulation of p38 MAPK.

Keywords    microRNA; diabetes; GK (Goto–Kakizaki) rat; Wistar rat; p38 MAPK

Received: December 16, 2008; Accepted: March 3, 2009

{dagger} These authors contributed equally to this work.


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