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Acta Biochimica et Biophysica Sinica 2009 41(5):352-361; doi:10.1093/abbs/gmp029
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© The Author 2009. Published by ABBS Editorial Office in association with Oxford University Press on behalf of the Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences.

Molecular properties, functions, and potential applications of NAD kinases

Feng Shi1,*, Yongfu Li2, Ye Li1 and Xiaoyuan Wang1

1 State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China
2 School of Food Science, Jiangnan University, Wuxi 214122, China

* Correspondence address. Tel/Fax: +86-510-85329236; E-mail: shifeng{at}jiangnan.edu.cn


  Abstract

NAD kinase catalyzes the phosphorylation of NAD(H) to form NADP(H), using ATP as phosphoryl donor. It is the only key enzyme leading to the de novo NADP+/NADPH biosynthesis. Coenzymes such as NAD(H) and NADP(H) are known for their important functions. Recent studies have partially demonstrated that NAD kinase plays a crucial role in the regulation of NAD(H)/NADP(H) conversion. Here, the molecular properties, physiologic functions, and potential applications of NAD kinase are discussed.

Keywords    NAD kinase; NAD+/NADH; NADP+/NADPH; coenzyme metabolism

Received: November 12, 2008; Accepted: February 12, 2009
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