Skip Navigation

Acta Biochimica et Biophysica Sinica 2009 41(3):188-197; doi:10.1093/abbs/gmp001
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Yin, X.
Right arrow Articles by Zhang, W.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Yin, X.
Right arrow Articles by Zhang, W.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2009. Published by ABBS Editorial Office in association with Oxford University Press on behalf of the Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences.

Ghrelin fluctuation, what determines its production?

Xuefeng Yin1, Yin Li1, Geyang Xu1, Wenjiao An1 and Weizhen Zhang1,2,*

1 Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing 100191, China
2 Department of Surgery, University of Michigan Medical Center, Ann Arbor, MI 48109-0346, USA

* Correspondence address. Tel: +86-10-82802183; Fax: +86-10-82802183; E-mail: weizhenzhang{at}bjmu.edu.cn


  Abstract

Ghrelin, a 28 amino acid gut brain peptide, acts as an endogenous ligand for its receptor, the growth hormone secretagogue receptor, to exercise a variety of functions ranging from stimulation of growth hormone secretion, regulation of appetite and energy metabolism, and cell protection to modulation of inflammation. This review summarizes the advance in the regulation of ghrelin expression and secretion. We introduce the structure of ghrelin promoter, the processing and modification of ghrelin precursor, and the regulation mechanism in these processes. Then we discuss factors found to be important in the regulation of ghrelin production, including nutrients, hormones, and autonomic nervous system. Finally, we outline the alteration in the level of ghrelin in certain physiological and pathological status.

Keywords    ghrelin; regulation; diet; secretion; biosynthesis

Received: September 2, 2008; Accepted: December 9, 2008
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
W. Zhang, A. Majumder, X. Wu, and M. W. Mulholland
Regulation of food intake and body weight by recombinant proghrelin
Am J Physiol Endocrinol Metab, December 1, 2009; 297(6): E1269 - E1275.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.