Skip Navigation


Acta Biochimica et Biophysica Sinica Advance Access originally published online on July 27, 2009
Acta Biochimica et Biophysica Sinica 2009 41(9):763-772; doi:10.1093/abbs/gmp065
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
41/9/763    most recent
gmp065v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Wang, Q.
Right arrow Articles by Tang, H.
PubMed
Right arrow Articles by Wang, Q.
Right arrow Articles by Tang, H.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2009. Published by ABBS Editorial Office in association with Oxford University Press on behalf of the Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences.

Kazrin F is involved in apoptosis and interacts with BAX and ARC

Qiong Wang1,2, Min Liu1, Xin Li1, Lu Chen1 and Hua Tang1,*

1 Tianjin Life Science Research Center, Tianjin Medical University, Tianjin 300070, China
2 Institute of Neurosurgery, Huanhu Hospital of Tianjin, Tianjin 300060, China

* Correspondence address. Tel/Fax: +86-22-23542503; E-mail: htang2002{at}yahoo.com


  Abstract

Kazrin has recently been identified as a functional protein that is involved in cell–cell junctions and in signal transduction. Here, we identified a new isoform, Kazrin F, which is 518 aa in length and has 97 aa unique at the N-terminus. Knockdown of Kazrin F using siRNA caused cell apoptosis and a marked decrease in cell viability measured by MTT and TUNEL assays. Co-immunoprecipitation analysis revealed that Kazrin F interacts with ARC (apoptosis repressor with caspase recruitment domain) and Bax (Bcl-2-associated X protein). Co-localization of Kazrin F with ARC and Bax in the cytoplasm was determined by immunofluorescence analysis. These results suggested that Kazrin F might play an important role in regulating cellular apoptosis by interacting with ARC and Bax.

Keywords    Kazrin F; apoptosis; ARC; Bax; caspase-3

Received: April 25, 2009; Accepted: June 2, 2009
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.