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Acta Biochimica et Biophysica Sinica Advance Access originally published online on July 21, 2009
Acta Biochimica et Biophysica Sinica 2009 41(8):631-637; doi:10.1093/abbs/gmp051
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© The Author 2009. Published by ABBS Editorial Office in association with Oxford University Press on behalf of the Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences.

Overexpression of VCC-1 gene in human hepatocellular carcinoma cells promotes cell proliferation and invasion

Xia Mu1,2, Yao Chen1, Shuihai Wang1, Xiang Huang1, Huazhen Pan1 and Ming Li1,*

1 School of Biotechnology, Southern Medical University, Guangzhou 510515, China
2 Institute for infectious disease, Guizhou Provincial Center for Disease Prevention and Control, Guiyang 550004, China

* Correspondence address. Tel: +86-20-61648550; Fax: +86-20-61648554; E-mail: mingli{at}fimmu.com


  Abstract

Vascular endothelial growth factor-correlated chemokine 1 (VCC-1), a novel chemokine, is hypothesized to be associated with carcinogenesis. VCC-1 is expressed in hepatocellular carcinoma (HCC) cells, but its function remains unknown. To investigate the molecular effects of VCC-1 on HCC cells, the HCC cell line SMMC7721 was stably transfected with the recombinant plasmid pcDNA3.1/VCC-1. Our data demonstrated that overexpression of VCC-1 in SMMC7721 cells significantly enhanced the cellular proliferation, invasive ability, and tumor growth, when compared with both empty vector control cells and parental cells. These results strongly suggest that VCC-1 plays an important role in SMMC7721 invasion and tumor growth, and indicate that VCC-1 may serve as a potential biomarker for anti-HCC therapies.

Keywords    chemokine; hepatocellular carcinoma; VCC-1; tumorigenesis

Received: February 13, 2009; Accepted: April 29, 2009
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