Skip Navigation


Acta Biochimica et Biophysica Sinica Advance Access originally published online on May 22, 2009
Acta Biochimica et Biophysica Sinica 2009 41(7):527-534; doi:10.1093/abbs/gmp040
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
41/7/527    most recent
gmp040v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Jiang, L.
Right arrow Articles by Song, L.
PubMed
Right arrow Articles by Jiang, L.
Right arrow Articles by Song, L.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2009. Published by ABBS Editorial Office in association with Oxford University Press on behalf of the Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences.

Bmi-1, stem cells and cancer

Lili Jiang1,2, Jun Li2 and Libing Song1,*

1 State Key Laboratory of Oncology in Southern China, Department of Experimental Research, Cancer Center, Sun Yat-sen University, Guangzhou 510060, China
2 Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China

* Correspondence address. Tel: +86-20-87343192; Fax: +86-20-87343171; E-mail: lb.song1{at}gmail.com


  Abstract

Bmi-1, a polycomb gene family member, plays an important role in cell cycle regulation, cell immortalization, and cell senescence. Recently, numerous studies have demonstrated that Bmi-1 is involved in the regulation of self-renewal and differentiation of stem cells. However, the molecular mechanism underlying this biological process remains largely unclear. In the present review, we summarized the function of Bmi-1 as a transcriptional regulator of gene expression, with particular reference to stem cells.

Keywords    Bmi-1; stem cell; self-renewal; cancer

Received: November 25, 2008; Accepted: April 2, 2009
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.