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Acta Biochimica et Biophysica Sinica 2009 41(6):437-445; doi:10.1093/abbs/gmp031
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© The Author 2009. Published by ABBS Editorial Office in association with Oxford University Press on behalf of the Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences.

The lysosome and neurodegenerative diseases

Lisha Zhang, Rui Sheng and Zhenghong Qin*

Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Soochow University School of Medicine, Suzhou 215123, China

* Correspondence address. Tel/Fax: +86-512-65880406; E-mail: zhqin5{at}hotmail.com


  Abstract

It has long been believed that the lysosome is an important digestive organelle. There is increasing evidence that the lysosome is also involved in pathogenesis of a variety of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis. Abnormal protein degradation and deposition induced by lysosomal dysfunction may be the primary contributor to age-related neurodegeneration. In this review, the possible relationship between lysosome and various neurodegenerative diseases is described.

Keywords    lysosome; neurodegenerative diseases; Alzheimer's disease; Parkinson's disease; Huntington's disease

Received: December 16, 2008; Accepted: February 25, 2009
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