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Acta Biochimica et Biophysica Sinica 2009 41(3):231-236; doi:10.1093/abbs/gmp006
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© The Author 2009. Published by ABBS Editorial Office in association with Oxford University Press on behalf of the Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences.

MicroRNA expression profiling during neural differentiation of mouse embryonic carcinoma P19 cells

Bing Huang1, Wei Li1, Botao Zhao1, Caihong Xia2, Ruqiang Liang1, Kangcheng Ruan1, Naihe Jing2 and Youxin Jin1,*

1 State Key Laboratory of Molecular Biology
2 Key Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, People's Republic of China

* Correspondence address. Tel: +86-21-54921222; Fax: +86-21-54921011; E-mail: yxjin{at}sibs.ac.cn


  Abstract

MicroRNAs (or miRNAs) are small non-coding RNAs (21–25 nucleotides) that are involved in a wide range of activities related to the development and differentiation of cells. Comparison of the miRNA expression profiles of mouse P19 embryonic carcinoma cells with those of differentiated neural stem cells showed that the expression level of 65 miRNAs changed (2-fold) after differentiation. MiR-124a was dramatically up-regulated (more than 20-fold) while miRNAs of the miR-302 family and those in the miR-290–295 cluster were strongly down-regulated. Further analysis revealed that some important factors such as Oct4 and Sox2 appeared to be involved in the regulation of these miRNAs. These results may contribute to a better understanding of miRNA-regulated neural differentiation in early mouse embryos.

Keywords    microRNA; embryonic carcinoma P19 cell; neural stem cells; neural differentiation

Received: October 7, 2008; Accepted: November 28, 2008
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