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Acta Biochimica et Biophysica Sinica Advance Access originally published online on September 3, 2009
Acta Biochimica et Biophysica Sinica 2009 41(10):809-815; doi:10.1093/abbs/gmp075
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© The Author 2009. Published by ABBS Editorial Office in association with Oxford University Press on behalf of the Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences.

Identification and characterization of an epididymis-specific gene, Ces7

Li Zhang1,2, Zhihong Hu1, Chunfang Zhu1, Qiang Liu1,*, Yuchuan Zhou1,* and Yonglian Zhang1,3

1 Shanghai Key Laboratory for Molecular Andrology, State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
2 The Graduate School of Chinese Academy of Sciences, Beijing 100049, China
3 Shanghai Institute of Planned Parenthood Research, Shanghai 200032, China

* Correspondence address. Tel: +86-21-54921267; Fax: +86-21-54921011; E-mail: qliu{at}sibs.ac.cn (Q.L.); Tel: +86-21-54921153; Fax: +86-21-54921011; E-mail: zhouych{at}sibs.ac.cn (Y.Z.)


  Abstract

Carboxylesterases (CEs) represent a multigene family of serine-dependent enzymes. Male-dependent CEs are over-expressed in the male reproductive tract of different animal species (bivalve mollusks, fruit-flies, and mammals). Here, a novel rat epididymis-specific gene named Ces7 was cloned and characterized. It was a novel member of CE family, which was mainly expressed and secreted to the lumens of the corpus and cauda epididymis. CES7 protein was highly glycosylated as other mammalian CEs. Furthermore, Ces7 increased with age growth until sex maturation and then maintained at high level. CES7 might be one of the major CEs in male reproductive tract and contribute to the sperm fertilization.

Keywords    epididymis; carboxylesterase; sperm maturation

Received: April 9, 2009; Accepted: May 21, 2009
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